Abstract
An efficient and direct protocol for the preparation of 1-amidoalkyl-2-naphthols employing a multi-component and one-pot condensation reaction of 2-naphthol, aromatic aldehydes, and acetamide in the presence of MoO3/SiO2 under solvent-free conditions is described. The reaction using a catalyst was carried out under mild condition with very high yields up to 93 %. The present approach of this methodology offers several advantages such as shorter reaction times, good yields, low cost, environmentally benign, milder reaction conditions, easy recovery of catalyst, and reusability.
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