Abstract
The multicomponent Mannich reaction is a green and classical method for the preparation of β-aminoketones and β-aminoaldehydes (Mannich bases) and, as such, is one of the most important reactions in organic chemistry. The resulting Mannich bases are of particular interest due to their biological activity as well as their use as synthetic building blocks and precursors of valuable pharmaceuticals products. In this context, various elegant methods for multicomponent Mannich reactions have been developing over last years. This review updates these reactions, including naphthoquinone derivatives that possess varied and important biological activities and whose Mannich reaction has been little explored in the literature.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
