Abstract
We have developed multicolour hybrid DNA probes employing green, yellow and orangecolour quantum dot conjugated molecular beacons with black hole quencher 2. Optical andelectrophoretic characterization revealed fluorescent energy transfer that follows the FRETmechanism with single nucleotide discrimination. Target DNA identification was observedto be highly sensitive up to 8 ng in gel electrophoresis. Comparison with the conventionalorganic dye SYBR Gold™ showed that our hybrid nanoprobes exhibit more stableperformance with less background signal.
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