Multichannel neural recording system based on family ASICs processed in submicron technology

Abstract

In this paper we present a measurement system for in vivo multichannel recordings of the electrophysiological activity of brain tissue. The system consists of penetrating Microelectrode Array (MEA), three versions of a Conditioning Module each equipped with different Application Specific Integrated Circuits (ASIC), Digitizer and PC Application for recorded data presentation and storage. The MEA consists of 64 15μm diameter microelectrodes. The multichannel ASICs amplify and filter field and action potential signals. The custom-made Digitizer Module simultaneously acquires data from all channels with a 14kS/s sample rate and 12bit resolution. The resulting byte stream (about 2MB/s) is transmitted to the PC via USB (Universal Serial Bus). Eventually the measurement data is decoded, presented to the system user and stored on a HDD. Preliminary system tests confirm its excellent performance (low input refereed noise, low power consumption, low area occupancy, ability of Action Potentials/Local Field Potentials separation). Our system equipped with multichannel ASICs meets requirements of many different neurobiology experiments.