Multichannel intraluminal impedance combined with manometry improves the evaluation of functional esophageal motility disorders in patients undergoing antireflux surgery for gastroesophageal reflux disease (GERD)

Abstract

well as the underlying reflux disease. Results: Since January 2000 402 patients were registered. Data of 361 patients (268 males / 93 females) were complete and analysed. 14 centers participated ( 3 surgical n = 214; 11 gastroenterologic n = 1 ~-9). Refluxsymptoms were present in 56 % of patients daily or weekly, in 25 % they were absent, sex: total (268 / 93); antirefluxoperated (101 / 28); PPl-treated 140/52 age: total (56,5 years (10-89)); antirefiuxoperated (52,7 y. (10-85)); PPI-treated (59,1 y. (19-89)) Duration history: total (10,8 years (0-50)); antirefluxoperated (11,2 y. (1-50)); PPl-treated (10,4 y. (0-45)); Barrett known: since total 235 days (14351); antirefluxoperated since 382 d. (1-4351); PPI-treated since 139 d. (2-857). 28 patients were initially documented vath dysplasia (19 LGD; 4 HGD; 5 indefinite) 3 HGD, 4 LGD und 4 indefinite patients showed at the next follow-up histology no dysplasia any more. From all patients only one was found to have a progressmn from IM to LGD in a total of 1187 documented patient-years. Conclusion: A central registration of data on the natural and posttherapeutic course of patients with Barrett-esophagns allows for a valid risk calculation of cancer progression in a given popuiation. The current analysis shows for PPi treatment as well for antireflux-surgery a low rate of progression.