Abstract
In dit artikel wordt een zes jaar oude, mannelijke dwerggeit met acute perifere lymfadenopathie beschreven die initieel begon met opzetting van de inguinale lymfeknopen. Op het lichamelijk onderzoek werd ook zwelling van de retrofaryngeale, de boeg- en de inguinale lymfeknopen vastgesteld. Serologisch onderzoek naar boviene leukemie, capriene artritis-encefalitisvirus en caseuze lymfadenitis was negatief. Cytologisch onderzoek van een dunnenaaldaspiraat van de prescapulaire lymfeknopen toonde multipele, grote lymfoblastische cellen. Vanwege de algemene klinische achteruitgang en slechte prognose werd besloten het dier te euthanaseren. Op autopsie werd een veralgemeende vergroting van de lymfeknopen waargenomen. Na histologisch en immunohistochemisch onderzoek van de lymfeknopen werd deze neoplasie als een multicentrisch B-cellymfoom gekarakteriseerd.
Highlights
Lymphoma is a sporadic disease in ruminants
Paraparesis has been reported in a case of lymphoma with involvement of the spinal cord (Gygi et al, 2004)
Fine needle aspirates of two enlarged peripheral lymph nodes were taken for cytologic evaluation and proved to be accurate for the diagnosis of lymphoma
Summary
Lymphoma is a sporadic disease in ruminants. It has been described in cattle (De Vliegher et al, 2000; Malatestinic, 2003; Schweizer et al, 2003; Braun et al, 2005; Duncan et al, 2005; Loh, 2007), sheep (Valenti and McDonough, 2003) and goats (Olson and Baumgartner, 1975; Olson et al, 1981a,b; Baker et al, 1982; Bakers and Sherman, 1982; Higgens et al, 1984; de Silva et al, 1985; Craig et al, 1986; Smith and Sherman, 1996; Puette and Lalimer, 1997), and in deer (Madson and Opriessnig, 2009; Kleinschmidt et al, 2012; Reissig et al, 2013) and water buffalo (Vale-Echeto, 2009). The clinical, pathologic and histologic examination of a six-year-old male goat with multicentric B-cell lymphoma is described. A thorough clinical examination was performed, but no significant abnormalities were detected, apart from mild swelling of the left inguinal lymph node. Clinical examination revealed swollen retropharyngeal, prescapular and inguinal lymph nodes (Figure 1). Fine needle aspirates were taken (20G needle, 4 cm long) from the left and right prescapular lymph node for cytological evaluation and stained with Hemacolor® (Merck KGaA, Germany). Both aspirates revealed a monomorphic population of large round cells (20-35μm) with a large dark blue and round nucleus and a small amount of light blue cytoplasm (Figure 2). This neoplasia was characterized as a multicentric large B-cell lymphoma
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