Abstract
BackgroundMulticentric reticulohistiocytosis is a rare form of non-langerhans cell histiocytosis presenting with skin changes and erosive arthritis. Infiltration of histiocytes and multinucleated giant cells are typical histological findings and confirm the diagnosis.Case presentationThis case report describes a newly diagnosed case of multicentric reticulohistiocytosis in a healthy 26-year-old female originally from the Philippines. Eruption of papules and nodules on the hands and pain in multiple joints were the main complaints at the initial presentation. Radiographical findings of erosions in the small hand and feet joints were impressive. Initial histological findings did not match the clinical image, although later the clinical diagnosis was supported by histological findings in additional biopsies.ConclusionsAlthough initial histological findings did not match the clinical image, additional biopsies were valuable to confirm the diagnosis.
Highlights
Multicentric reticulohistiocytosis is a rare form of non-langerhans cell histiocytosis presenting with skin changes and erosive arthritis
The prevalence of multicentric reticulohistiocytosis is not exactly known, approximately 300 cases have been reported in medical literature
The course and outcome of multicentric reticulohistiocytosis are unpredictable and the disease is often self-limiting, joint deformities remain as non-denying remnants of the disease [3]
Summary
Multicentric reticulohistiocytosis is a rare form of non-langerhans cell histiocytosis presenting with skin changes and erosive arthritis. Conclusions: initial histological findings did not match the clinical image, additional biopsies were valuable to confirm the diagnosis. Goltz and Laymon proposed the name multicentric reticulohistiocytosis in 1954 because of the multifocal origin and systemic nature of the disease [2].
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