Abstract
Invasive Pleomorphic Lobular Carcinoma is a very rare histopathological variant of breast cancer. It constitutes less than 1% of invasive breast carcinoma .We present a 70 year female presented with lump in right breast of 10 months duration. The lump was insidious in onset, progressive in nature and was associated with gradual skin color changes. Patient was a known diabetic and was on regular treatment. On fine needle aspiration cytology showed positive for carcinoma cells. Right modified mastectomy was performed. On histopathology reported as Invasive Pleomorphic Lobular Carcinoma – Grade II with multicentric nodules. Right axillary lymph nodes with perinodal infiltration of tumor were noted. We are presenting this case for its uncommon type, clinical, histomorphological and immunohistochemistry pattern.
Highlights
Invasive Pleomorphic Lobular Carcinoma (IPLC) is one of the distinctive subtypes of invasive breast carcinoma
IPLC was first described by Martinez V and Azzopardi in 1979,[1] and later on in 1987 by Page and Anderson. [2]Invasive pleomorphic lobular carcinoma represents less than 1% of invasive carcinomas.[3]Unlike the classic variant, the tumor cells of the pleomorphic variant of Infiltrating lobular carcinoma (ILC) are larger in size, large irregular, pleomorphic, hyperchromatic nuclei with occasional prominent nucleoli and having abundant eosinophilic cytoplasm
Tumor was seen diffusely infiltrating in single file with dense fibrovascular stroma separating the tumor.(Figure-2 A,B,C,D.). It was reported as Invasive Pleomorphic Lobular Carcinoma Areas of classical and alveolar pattern were noted
Summary
Invasive Pleomorphic Lobular Carcinoma (IPLC) is one of the distinctive subtypes of invasive breast carcinoma. Serial cut sections through the specimen, revealed a grey white, firm tumor measuring 10 x 4.5 x 2 cm, located in subareolar region. Cut section of which revealed grey white firm tumor .Serial sectioning showed three lymph nodes in axillary region ( along the specimen ), largest measuring 1.2 x 0.8 x 0.3 cm. On microscopic examination showed a tumor is composed of neoplatic cells arranged in cords, Indian file pattern, small nests, and alveolar pattern and scattered diffusely and multifocally in the breast parenchyma. Tumor was seen diffusely infiltrating in single file with dense fibrovascular stroma separating the tumor.(Figure-2 A,B,C,D.) On histopathological examination, it was reported as Invasive Pleomorphic Lobular Carcinoma Areas of classical and alveolar pattern were noted. Our patient received treatment of right sided modified radical mastectomy with axillary clearance.
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