Multicentric Giant Cell Tumor of Bone: Synchronous and Metachronous Presentation

Reiner Wirbel,Veit Krenn,Dirk Lommel,Guido Syré,Frank Blümler

doi:10.1155/2013/756723

Abstract

A 27-year-old man treated 2.5 years ago for synchronous multicentric giant cell tumor of bone located at the right proximal humerus and the right 5th finger presented now with complaints of pain in his right hip and wrist of two-month duration. Radiology and magnetic resonance revealed multicentric giant cell tumor lesions of the right proximal femur, the left ileum, the right distal radius, and the left distal tibia. The patient has an eighteen-year history of a healed osteosarcoma of the right tibia that was treated with chemotherapy, resection, and allograft reconstruction. A literature review establishes this as the first reported case of a patient with synchronous and metachronous multicentric giant cell tumor who also has a history of osteosarcoma.

Highlights

Giant cell tumors (GCT) of bone account for 4% to 5% of all primary bone tumors [1–3]
A literature review establishes this as the first reported case of a patient with synchronous and metachronous multicentric giant cell tumor who has a history of osteosarcoma
Giant cell tumor (GCT) of bone is a benign primary neoplasm accounting for 4% to 5% of all primary bone tumors [1–4]

Summary

Introduction

Giant cell tumors (GCT) of bone account for 4% to 5% of all primary bone tumors [1–3]. Multicentricity of GCT of bone is an extreme rarity accounting for less than 1% of these tumors. The biological behaviour and the clinical presentation (e.g., localization, age, and gender distribution) seem to be different from solitary lesions [1–3]. We like to present an additional case of a patient with multicentric giant cell tumor of bone. The typical features of multicentricity should be pointed out

Case Presentation

Discussion

Findings

Conflict of Interests