Abstract
Poster presentation Association of CD and RA is widely described in adults, but has never been reported in children with JIA. We report a 13 years old girl with a 6 years history of polyarticular JIA treated with Methotrexate (MTX) since diagnosis and after 2 years, in April 2004, started on etanercept. On this treatment, patient presented important clinical improvement which allowed steroids withdrawal and progressive reduction of MTX. In June 2007 recurrent attacks of migraine appeared with negative EEG and cerebral MRI. In November headache became continuous and after one month morning palpebral oedema and right chest pain appeared, followed by vomiting which lead to hospitalisation in January 2008. Noticeable elements on physical examination were: systolic hypertension, papilledema, palpebral and peripheral oedema, generalized lymphoadenopathy and hepatomegaly. Relevant lab tests were: Hb 11.6 g/dL, ESR 67 mm/h, CRP 21.6 mg/L, hematuria, nephrotic proteinuria. Viral, bacterial and fungal infections were ruled out. Cerebral MRI showed right emisphere and right tentorial dural thickening (pachymeningitis). CT and ultrasound confirmed the presence of enlarged mediastinal and axillary lymph nodes, pericardial and pleural effusion, bilateral renal enlargement and ascites. Plasmocytosis was found on bone marrow aspirate. Axillary lymph node biopsy was consistent with CD. To our knowledge this the first report of the combination of two conditions rarely associated with RA, multicentric CD and pachymenigitis, in a child with JIA in remission under treatment with etanercept. This raises the question whether anti TNF-? therapy might contribute to lymphoproliferation possibly via dysregulation of cytokines network
Highlights
Multicentric Castleman's Disease (CD) in juvenile idiopathic arthritis (JIA) treated with etanercept: coincidence or causal relationship?
15th Paediatric Rheumatology European Society (PreS) Congress Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
Association of CD and RA is widely described in adults, but has never been reported in children with JIA
Summary
Multicentric Castleman's Disease (CD) in juvenile idiopathic arthritis (JIA) treated with etanercept: coincidence or causal relationship?. L Rossi*, G Martini, L Sainati and F Zulian Address: Department of Paediatrics, Padova, Italy * Corresponding author from 15th Paediatric Rheumatology European Society (PreS) Congress London, UK. Published: 15 September 2008 Pediatric Rheumatology 2008, 6(Suppl 1):P56 doi:10.1186/1546-0096-6-S1-P56
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