Multicentric breast cancer with heterogeneous histopathology: a multidisciplinary review.

Abstract

Multiple synchronous (multifocal or multicentric) ipsilateral breast cancers with heterogeneous histopathology area rare clinical occurrence, however, their incidence is increasing due to the use of MRI for breast cancer screening and staging. Some studies have demonstrated poorer clinical outcomes for this pattern of breast cancer, but there is no evidence to guide clinical practice. In this multidisciplinary review, we reflect on pathology and molecular characteristics, imaging findings, surgical management including conservation and reconstructive options and approach to the axilla, and the role of chemotherapy and radiotherapy. Multidisciplinary discussions appeardecisive in planning an appropriate surgical choice and defining the correct systemic treatmenttailored to each clinical condition.