Multicenter Study: Effectiveness and Efficiency of Prabotulinum Toxin-A Injection on Wrinkles in Forehead, Crow’s Feet, and Glabellar

Abstract

BACKGROUND OF THE STUDY: Prabotulinumtoxin A (PRA) is the newest type A botulinum toxin produced by wild-type Clostridium botulinum. Prabotulinumtoxin A has a higher purity level than onabotulinum toxin A, but the literature discussing it is still limited and requires more research on its effectiveness.
 AIM OF THE STUDY: This research aimed to examine the efficacy of Prabotulinumtoxin A on wrinkles in forehead, crow’s feet and glabellar.
 METHODOLOGY: This research was a pre- and post-test, multicenter study from 3 center in Indonesia. Subjects will be observed at week 0, week 2, week 4, week 8 and week 12. Injection of prabotulinumtoxin A (INIBOÒ, Covaltt, South Korea) was performed intramuscularly on forehead, crow's feet, and glabellar with a dose of 4 IU / 0.1 ml. The measurement uses a scoring from the Upper Face Rating Scale. Different statistical test with repeated measurement test was conducted to compare the results between observations. The statistical test uses a confidence level of 0.95 with an error rate (α) = 0.05.
 RESULTS: The results of this study showed that Prabotulinumtoxin A injection was effective in reducing wrinkles in the frontal, glabellar and crow's feet area, with a statistically significant difference between week 0 and week 12.
 CONCLUSION: Prabotulinumtoxin A products improve the condition of wrinkles with a fairly good level of satisfaction and efficacy. Observations of more than 12 weeks are needed to determine the duration of Prabotulinumtoxin A products.