Abstract
To evaluate the outcomes of endovascular repair using three-vessel inner branch aortic arch stent-grafts for aneurysms and chronic dissections. We reviewed the clinical data and outcomes of consecutive patients treated by total endovascular aortic arch repair at eight academic centers using three-vessel inner branch stent grafts (William Cook Europe, Bjaeverskov, Denmark) between 2016 and 2019. All patients received patient-specific stent designs with two antegrade and one retrograde inner branch, which was used to incorporate the innominate, left common carotid, and left subclavian arteries. The antegrade inner branches were accessed via axillary or carotid artery access. A preloaded catheter was used for access to the retrograde left subclavian artery branch via femoral approach (Fig). End points were technical success, mortality, major adverse events, any stroke (minor or major) or transient ischemia attack, secondary interventions, target vessel patency, target vessel instability, aneurysm-related mortality and patient survival. There were 39 patients (31 male patients [79%], mean age 70 ± 7 years) treated for 14 (36%) degenerative and 25 (64%) chronic postdissection arch aneurysms. Clinical characteristics included American Society of Anesthesiologists classification of >3 in 37 patients (95%) and prior median sternotomy for ascending aortic repair in 33 patients (85%). Technical success rate was 100%. There were two in-hospital or 30-day deaths (5%) and two strokes (one minor). Combined mortality/any stroke rate was 8% (n = 3). Major adverse events occurred in 10 patients (26%), including respiratory failure in 4 patients (10%) and estimated blood loss of >1 L, myocardial infarction and acute kidney injury in two patients each (5%). Mean follow-up was 8 ± 10 months. Twelve patients (31%) required secondary interventions to treat vascular access complications in five patients, endoleak in six patients (three type II, one type IC, one type IB, one type IIIA) and target vessel stenosis in one patient. At 1 year, primary and secondary patency rates and freedom from target vessel instability were 95% ± 5%,100%, and 92% ± 5%, respectively. Freedom from aortic-related mortality and patient survival were 94% ± 4% and 90% ± 6%, respectively. This multicenter global experience demonstrates the technical feasibility and safety of total endovascular aortic arch repair for aneurysms and chronic dissections using three-vessel inner branch stent grafts. Mortality and stroke rates compare favorably to reported outcomes of total open surgical arch replacement, particularly among higher risk patients who had prior median sternotomies and ascending aortic repairs. A limitation remains the high rate of secondary reinterventions (31%), emphasizing need for larger experience and longer follow-up.
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