Abstract
The minimum inhibitory concentrations of 6 broad-spectrum β-lactam antimicrobial agents were determined by use of the Etest versus a total of 569 bacteria in 7 Puerto Rican hospital laboratories. These included 342 recent clinical isolates of Enterobacteriaceae, 63 Pseudomonas aeruginosa, 54 Acinetobacter species, and 110 oxacillin-susceptible staphylococci. Extended spectrum β-lactamase production was noted among 11% of Klebsiella pneumoniae isolates. Hyperproduction of Amp C cephalosporinase was observed with >20% of isolates of Enterobacter spp., Serratia spp., and Citrobacter freundii. The overall rank order of activity of the six β-lactams examined in this study versus all clinical isolates was imipenem (95.8% susceptible) > cefepime (91.1%) > piperacillin/ tazobactam (82.3%) > cefotaxime (77.6%) > piperacillin (72.5%) > ceftazidime (67.0%).
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