Multicenter epidemiologic study on hepatocellular carcinoma in Turkey.

Alper Can,Mehmet Besiroglu,Turgut Kacan,Derya Kivrak,Ummugul Uyeturk,Ahmet Cumhur Dulger,Nedim Turan,Ali Murat Tatli,Murat Kocer,Mehmet Fatih Ozbay,Oznur Bal,Sehmus Olmez,Ibrahim Vedat Bayoglu,Zuat Orakci,Erkan Dogan,Ahmet Alacacioglu

doi:10.7314/apjcp.2014.15.6.2923

Alper Can, Mehmet Besiroglu + Show 14 more

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https://doi.org/10.7314/apjcp.2014.15.6.2923

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Abstract

Hepatocellular cancer (HCC) is one of the important health problems in Turkey, being very common and highly lethal. The aim of this study was to determine clinical, demographic features and risk factors. Nine hundred and sixth-three patients with HCC from 13 cities in Turkey were included in this study. Only 205 (21%) of the 963 patients were women, with a male:female predominance of 4.8:1 and a median age of 61 years. The etiologic risk factors for HCC were hepatitis B in 555 patients (57.6%), 453 (81%) in men, and 102 (19%) in women, again with male predominance, hepatitis C in 159 (16.5%), (14.9% and 22.4%, with a higher incidence in women), and chronic alcohol abuse (more than ten years) in 137 (14.2%) (16.8% and 4.9%, higher in males). The Child-Pugh score paralleled with advanced disease stage amd also a high level of AFP. According to our findings the viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor. The Child-Pugh classification and AFP levels were determined to be important prognostic factors in HCC patients.

Highlights

Hepatocellular carcinoma (HCC) is one of the common tumors in the world
Materials and Methods: Nine hundred and sixth-three patients with Hepatocellular cancer (HCC) from 13 cities in Turkey were included in this study
Patients were classified in 3 groups, according to their alpha fetoprotein (AFP) levels

Summary

Introduction

Hepatocellular carcinoma (HCC) is one of the common tumors in the world. It is the 5th and 8th most common malignancy in men and woman respectively (Monto et al, 2001). Chronic liver disease and cirrhosis, is the most common cause of HCC. Hepatitis B and C viruses are the most common factors of chronic liver disease and cirrhosis (Monto et al, 2001; ). The etiologic risk factors for HCC were hepatitis B in 555 patients (57.6%), 453 (81%) in men, and 102 (19%) in women, again with male predominance, hepatitis C in 159 (16.5%), (14.9% and 22.4%, with a higher incidence in women), and chronic alcohol abuse (more than ten years) in 137 (14.2%) (16.8% and 4.9%, higher in males). Conclusions: According to our findings the viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor. The Child-Pugh classification and AFP levels were determined to be important prognostic factors in HCC patients

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