Multicenter analysis of gestational trophoblastic neoplasia in Turkey.

S Sinan Ozalp ,Macit Arvas,Taner Turan,Hakan Camuzoglu,Mehmet Kefeli,Hakan Yetimalar,Derya Sakarya Kilic,Levent Akman,Mehmet Dolanbay,Nadire Tuncer,Nurettin Boran,Serdar Serin,Gonca Ogurlu,Hasan Bozkaya,Süleyman Güven ,Emek Döğer ,Deniz Kulaksız ,K Yüce ,Gökhan Tosun ,Ali Özler ,Nedim Tokgözoğlu ,Yunus Yıldız ,Elçin Telli ,Tayyup Şimşek ,Füsun Varol ,Tayfun Güngör ,Tugan Beşe ,Gökhan Tulunay ,Bülent Çakmak ,Selen Doğan ,A Onan ,Eray Çalışkan ,Muzaffer Şancı ,Pınar Solmaz Hasdemir ,Tufan Öğe ,Mustafa Coşan Terek ,Ali Yanık ,Müfit Cemal Yenen ,Bülent Özçelik ,Yılmaz Dikmen ,Tevfik Güvenal ,Mehmet Gökçü ,Serkan Kuruoğlu ,Zehra Kurdoğlu ,Murat Apı ,Emre Özgü ,Hasan Yüksel ,Volkan Ülker ,Arif Kökçü ,Kadir Güzin ,Fuat Demirkıran ,Dağıstan Tolga Ariöz ,Aydın Özsaran ,Tayfun Toptaş ,Tolgay Tuyan İlhan

doi:10.7314/apjcp.2014.15.8.3625

S Sinan Ozalp , Macit Arvas + Show 53 more

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https://doi.org/10.7314/apjcp.2014.15.8.3625

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Abstract

To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated. From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients. Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.

Highlights

Gestational trophoblastic neoplasia (GTN) is the malignant form of gestational trophoblastic disease and includes invasive mole, choriocarcinoma, placental site trophoblastic tumors (PSTTs) and epitheloid trophoblastic tumors (ETTs) (May et al, 2011)
A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively
352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients

Summary

Introduction

Gestational trophoblastic neoplasia (GTN) is the malignant form of gestational trophoblastic disease and includes invasive mole, choriocarcinoma, placental site trophoblastic tumors (PSTTs) and epitheloid trophoblastic tumors (ETTs) (May et al, 2011). In another study from a similar part of Turkey, the incidence of choriocarcinoma was 2.35 per 1,000 deliveries (Gul et al, 1997). The incidence of invasive mole, choriocarcinoma and PSTTs was determined to be 0.16, 0.38 and 0.1 per 1,000 deliveries, respectively, in eastern Turkey (Kurdoglu et al, 2011). Diagnosis and management of GTN among 28 centers in Turkey. A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Conclusions: Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN

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