Multi‐Tissue Organoid Engineering: Bio‐assembling Macro‐Scale, Lumenized Airway Tubes of Defined Shape via Multi‐Organoid Patterning and Fusion (Adv. Sci. 9/2021)

Abstract

In article number 2003332 by Joo-Hyeon Lee, Yan Yan Shery Huang, and co-workers, a robust organoid engineering method is developed to ‘up-size’ and ‘shape’ organoids—miniature collections of cells which mimic biological features of an organ. The method, named Multi-Organoid Patterning and Fusion (MOrPF), is used to assemble scaffold-free macroscale airway tubes, leading to flowable organoid-on-a-chip, and branching tubular structures. The organoid fusion process is characterised by inter-organoid surface integration, luminal clearance, and lumina connection.