Multi-thermo responsive double network composite hydrogel for 3D printing medical hydrogel mask

Abstract

3D printing of multifunctional hydrogels offers great opportunities for developing innovative biomedical technologies as it can provide custom-designed shapes and structures conformal to arbitrary contours. There have been significant improvements of the 3D printing techniques, but the available printable hydrogel materials limit the progress. Here, we investigated the use of a poloxamer diacrylate (Pluronic P123) to augment the thermo-responsive network composed of poly(N-isopropylacrylamide) and develop a multi-thermoresponsive hydrogel for photopolymerization 3D printing. The hydrogel precursor resin was synthesised to be printable with high-fidelity of fine structures and once cured can form a robust thermo-responsive hydrogel. By utilizing N-isopropyl acrylamide monomer and a Pluronic P123 diacrylate crosslinker as 2 separate thermo-responsive components it was found that the final hydrogel displayed 2 distinct lower critical solution temperature (LCST) switches. This enables the loading of hydrophilic drugs at fridge temperature and improving the strength of the hydrogel at room temperature while still maintaining a drug release at body temperature. The thermo-responsive material properties of this multifunctional hydrogel material system were investigated, showing a significant promise as a medical hydrogel mask. Furthermore, it is demonstrated that it can be printed in sizes large enough to fit and adhere to a human face at 1:1 scale with high dimensional accuracy, as well as its ability to load with hydrophilic drugs.