Abstract
Organic chemistry is continually evolving to improve the syntheses of value added and bioactive compounds. Through this progression, a concomitant advancement in laboratory technology has occurred. Many researchers now choose to mediate transformations in continuous-flow systems given the many benefits over round bottom flasks. Furthermore, reaction scale up is often less problematic as this is addressed at the inception of the science. Although single-step transformations in continuous-flow systems are common, multi-step transformations are more valuable. In these systems, molecular complexity is accrued through sequential transformations to a mobile scaffold, much like an in vitro version of Nature's polyketide synthases. Utilizing this methodology, multi-step continuous-flow systems have improved the syntheses of active pharmaceutical ingredients (APIs), natural products, and commodity chemicals. This Review details these advancements while highlighting the rapid progress, benefits, and diversification of this expanding field.
Highlights
Translating synthesis into multi-step continuous-flow is a rapidly expanding and diversifying area in the chemical sciences, with rapid advances in equipment effective for gaining access to active pharmaceutical ingredients, natural products, and commodity chemicals
Multi-step continuous-flow systems have improved the syntheses of active pharmaceutical ingredients (APIs), natural products, and commodity chemicals
(5) Active Pharmaceutical Ingredients (APIs), natural products and commodity chemicals have benefited from continuous-flow syntheses
Summary
This section examines multi-step continuous-flow functional group transformations. In each of the examples, the benefits of mediating the reaction in continuous-flow have been highlighted. The purpose of this section is to provide a source of inspiration for future transformations while exploring the benefits of continuous-flow systems over round bottom flasks
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