Abstract
A hypothetical model for cell differentiation is presented. The genome should contain a number of bistable trigger systems composed of two genes G 1 and G 2, each gene synthetizing a repressor for the other gene. In each stable state of the trigger only one repressor is synthetized, which inhibits the other gene. Stability of such states is obtained if one assumes that the repressor anihilates the synthesis of the messenger RNA molecule if it combines with the active gene before the completion of the RNA molecule synthesis. The differentiation process is imagined as a series of “switches” of the triggers provoked by external inducers, the protein synthesis being directed from growth and division towards specialized activities. Implications of cancerization are discussed.
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