Abstract
The musculoskeletal system, containing bones, cartilage, skeletal muscles, tendons, ligaments, and some other tissues, is a perfect system that undergoes the external and internal load properly and controls the body’s motion efficiently. In this system, skeletal muscle is obviously indispensable. People have been studying the mystery of skeletal muscle mechanics for the last 80 years. Many modeling methods have been used to study skeletal muscles. Among these methods, multi-scale modeling methods are increasingly frequently used in studying musculoskeletal systems, especially those of skeletal muscles. In this review, we summarize the multi-scale modeling methods in studying works of skeletal muscle modeling reported so far. Then, several multi-scale methods of other tissues which possibly could be used in research on skeletal muscle modeling are discussed. Finally, the future research direction and the main challenges of multi-scale skeletal muscle modeling are briefly presented.
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