Abstract
It has long been assumed that the learning process changes the shape and connectivity of the cells in our brains. But no one has been able to observe this process while it is happening. By combining advanced microscopic imaging techniques with multi-electrode array recording and stimulation, we can determine the relationships between the morphology of brain cells and their electrical activity. We developed a system for studying learning and memory in cultured neuronal networks (Fig.1). By using in vitro approaches, one has access to every cell in the neural circuit, something that is not possible in living animals.
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