Abstract
Introduction: Multiorgan dysfunction (MOD) is one of the four consensus based criteria for the diagnosis of intrapartum asphyxia. The theoretical concept behind MOD is the diving reflex -conservation of blood flow to vital organs at the cost of non-vital organs. The objective of this study was to assess the patterns of involvement of each major organ/system in term asphyxiated neonates.Material and Methods: This was a hospital based prospective study. Sixty term neonates who had suffered perinatal asphyxia were assessed for central nervous system, kidney, cardiovascular system, gastrointestinal system and liver dysfunction. Results: Out of 60 eligible neonates, 57 (95%) had evidence of at least one organ dysfunction. Cardiovascular system involvement (95%) was most common, followed by renal system (37%), hepatic system (22%), central nervous system and hematological system (20% each) and finally, gastrointestinal tract (8%).Conclusion: MOD is frequently associated with perinatal asphyxia with cardiovascular system being the most commonly affected.J Nepal Paediatr Soc 2015;35(3):307-311.
Highlights
Multiorgan dysfunction (MOD) is one of the four consensus based criteria for the diagnosis of intrapartum asphyxia
Perinatal asphyxia refers to a condi on during the first and second stage of labor in which impaired gas exchange leads to fetal hypoxemia and hypercarbia[1]
Obstetric and pediatric associa ons have opined that dysfunc on of organs other than the central nervous system is a common feature of perinatal asphyxia.[2]
Summary
Multiorgan dysfunction (MOD) is one of the four consensus based criteria for the diagnosis of intrapartum asphyxia. The theoretical concept behind MOD is the diving reflex -conservation of blood flow to vital organs at the cost of non-vital organs. The objective of this study was to assess the patterns of involvement of each major organ/system in term asphyxiated neonates. Sixty term neonates who had suffered perinatal asphyxia were assessed for central nervous system, kidney, cardiovascular system, gastrointestinal system and liver dysfunction. Obstetric and pediatric associa ons have opined that dysfunc on of organs other than the central nervous system is a common feature of perinatal asphyxia.[2] The phenomenon of mul organ dysfunc on (MOD) is due to asphyxia induced diving reflex that leads to shun ng of blood from non-vital organs like skin to vital organs like heart, adrenals and brain to protect these organs from hypoxic-ischemic (HI) injury. The objec ve of the study was to assess the frequency and pa ern of involvement of each major organ system and combina on of organs in infants with post-asphyxial encephalopathy
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