Abstract
Coronary stents for treating atherosclerosis are traditionally manufactured from metallic alloys. However, metal stents permanently reside in the body and may trigger undesirable immunological responses. Bioresorbable polymer stents can provide a temporary scaffold that resorbs once the artery heals but are mechanically inferior, requiring thicker struts for equivalent radial support, which may increase thrombosis risk. This study addresses the challenge of designing mechanically effective but sufficiently thin poly(L-lactic acid) stents through a computational approach that optimises material properties and stent geometry. Forty parametric stent designs were generated: cross-sectional area (post-dilation), foreshortening, stent-to-artery ratio and radial collapse pressure were evaluated computationally using finite element analysis. Response surface methodology was used to identify performance trade-offs by formulating relationships between design parameters and response variables. Multi-objective optimisation was used to identify suitable stent designs from approximated Pareto fronts and an optimal design is proposed that offers comparable performance to designs in clinical practice. In summary, a computational framework has been developed that has potential application in the design of high stiffness, thin strut polymeric stents.
Highlights
Balloon angioplasty, performed by Andreas Gruntzig in 1977, is recorded as the first successful effort to treat an occluded coronary artery and subsequently revolutionised the treatment of coronary artery disease [1]
To the best of the authors’ knowledge, no study has considered the combined effect of the biaxial stretching processing history and the geometric configuration when optimising the mechanical performance of a poly(L-lactic acid) (PLLA) coronary stent
The baseline design recoiled by approximately 9% following dilation, which is comparable to commercial PLLA bioresorbable stents (BRSs) [24]
Summary
Balloon angioplasty, performed by Andreas Gruntzig in 1977, is recorded as the first successful effort to treat an occluded coronary artery and subsequently revolutionised the treatment of coronary artery disease [1]. The surgical procedure suffers from significant limitations, namely vessel occlusion and restenosis, which prompted the development of the first. Multi-objective optimisation of material properties and strut geometry for poly(L-lactic acid) coronary stents
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