Abstract
.Significance: Diffuse optical spectroscopic imaging (DOSI) is a versatile technology sensitive to changes in tissue composition and hemodynamics and has been used for a wide variety of clinical applications. Specific applications have prompted the development of versions of the DOSI technology to fit specific clinical needs. This work describes the development and characterization of a multi-modal DOSI (MM-DOSI) system that can acquire metabolic, compositional, and pulsatile information at multiple penetration depths in a single hardware platform. Additionally, a 3D tracking system is integrated with MM-DOSI, which enables registration of the acquired data to the physical imaging area.Aim: We demonstrate imaging, layered compositional analysis, and metabolism tracking capabilities using a single MM-DOSI system on optical phantoms as well as in vivo human tissue.Approach: We characterize system performance with a silicone phantom containing an embedded object. To demonstrate multi-layer sensitivity, we imaged human calf tissue with a 4.8-mm skin-adipose thickness. Human thenar tissue was also measured using a combined broadband DOSI and continuous-wave near-infrared spectroscopy method ( acquisition rate).Results: High-resolution optical property maps of absorption () and reduced scattering () were recovered on the phantom by capturing over 1000 measurement points in under 5 minutes. On human calf tissue, we show two probing depth layers have significantly different () total-hemo/myoglobin and composition. On thenar tissue, we calculate tissue arterial oxygen saturation, venous oxygen saturation, and tissue metabolic rate of oxygen consumption during baseline and after release of an arterial occlusion.Conclusions: The MM-DOSI can switch between collection of broadband spectra, high-resolution images, or multi-depth hemodynamics without any hardware reconfiguration. We conclude that MM-DOSI enables acquisition of high resolution, multi-modal data consolidated in a single platform, which can provide a more comprehensive understanding of tissue hemodynamics and composition for a wide range of clinical applications.
Highlights
Diffuse optical spectroscopic imaging (DOSI) is a versatile, non-invasive technology that is sensitive to tissue composition and hemodynamics
There is extensive literature describing the wide variety of clinical applications for DOSI ranging from breast cancer to exercise physiology.[1,2,3,4,5,6,7]
In previous work, using a DOSI-guided differential diagnosis method, the broadband spectral differences were compared between a breast with a benign or malignant tumor and the contralateral normal breast to demonstrate that analysis of multiple tissue layers with DOSI may supplement standard-of-care methods to determine tumor malignancy.[5]
Summary
Diffuse optical spectroscopic imaging (DOSI) is a versatile, non-invasive technology that is sensitive to tissue composition and hemodynamics. Obtained hemodynamic biomarkers have been identified as key indicators of hemorrhage and resuscitation.[15,16,17,18,19] While DOSI has been a valuable complement for a wide variety of clinical applications, advancement of the instrumentation to collect multiple modalities and accurately track handpiece position in a single device is important for constrained clinical settings, capturing faster physiological signals, and for rapid visualization of the images corresponding to the physical, mapped area
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