Abstract
local recurrences in either group (pZ0.484). There were 3 regional recurrences in the 66 Gy group and 0 in the 60 Gy cohort (pZ0.205). Distant metastases developed in 14 patients, 9 in the 66 Gy group and 5 in the 60 Gy cohort (pZ0.876). Notably, patients treated to 66 Gy were significantly more likely to require a G-tube (pZ0.042) and to require a permanent G-tube (pZ0.004). Conclusions: These results suggest that treating high-risk p16+ OPSCC with postoperative IMRT to 60 Gy does not adversely affect cancer-related outcomes compared to 66 Gy. De-escalation of the radiation dose to 60 Gy was associated with a significantly reduced need for a G-tube. Further examination of dose de-escalation in treating p16+ OPSCC in prospective studies is warranted. Author Disclosure: R. Chin: None. C.R. Spencer: None. M.Y. Hwang: None. P. Patel: None. H. Gay: None. B.H. Haughey: None. B. Nussenbaum: None. D. Adkins: None. J.S. Lewis: None. W.L. Thorstad: None.
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