Multi-functional, multicompartmental hyaluronan-binding protein 1 (HABP1/p32/gC1qR): implication in cancer progression and metastasis.

Paramita Saha,Kasturi Datta

doi:10.18632/oncotarget.24082

Abstract

Cancer is a complex, multi-factorial, multi-stage disease and a global threat to human health. Early detection of nature and stage of cancer is highly crucial for disease management. Recent studies have proved beyond any doubt about the involvement of the ubiquitous, myriad ligand binding, multi-functional human protein, hyaluronan-binding protein 1 (HABP1), which is identical to the splicing factor associated protein (p32) and the receptor of the globular head of the complement component (gC1qR) in tumorigenesis and cancer metastasis. Simultaneously three laboratories have discovered and named this protein separately as mentioned. Subsequently, different scientists have worked on the distinct functions in cellular processes ranging from immunological response, splicing mechanism, sperm-oocyte interactions, cell cycle regulation to cancer and have concentrated in their respective area of interest, referring it as either p32 or gC1qR or HABP1. HABP1 overexpression has been reported in almost all the tissue-specific forms of cancer and correlated with stage and poor prognosis in patients. In order to tackle this deadly disease and for therapeutic intervention, it is imperative to focus on all the regulatory aspects of this protein. Hence, this work is an attempt to combine an assortment of information on this protein to have an overview, which suggests its use as a diagnostic marker for cancer. The knowledge might assist in the designing of drugs for therapeutic intervention of HABP1/p32/gC1qR regulated specific ligand mediated pathways in cancer.

Highlights

Extracellular matrix (ECM) is crucial for the maintenance of tissue architecture, but it essentially regulates gene expression under normal condition as well as during pathophysiological conditions, which include tumor progression and metastasis
Hyaluronan-binding protein 1 synonymous as hyaluronan-binding protein 1 (HABP1)/ p32/gC1qR, located on human chromosome17p13.3 is a multiligand, multicompartmental www.impactjournals.com/oncotarget and multi-functional protein. This protein has been reported to regulate diverse cellular functions such as adhesion, cellular growth, immunity, migration, apoptosis and last but not the least the processes involved in cancer progression
Several clinical reports have proved beyond any doubt the augmented expression of HABP1/ p32/gC1qR in serum and tissues of patient samples, suggesting its probable use as a diagnostic and prognostic marker

Summary

Introduction

Extracellular matrix (ECM) is crucial for the maintenance of tissue architecture, but it essentially regulates gene expression under normal condition as well as during pathophysiological conditions, which include tumor progression and metastasis. A family of proteins termed as ‘hyaladherins’ having link protein B-(X)7-B motif, binds to HA, which reportedly mediate the diverse ligand multitude cellular activities [2] and regulate tumor formation and progression of cancer [3, 4].

Results

Conclusion