Abstract
Inflammatory bowel diseases are autoimmune and chronic diseases that affect the gastrointestinal tract and cause epithelial injuries. 5- aminosalicylic acid, also known as Mesalamine is currently widely used to obtain the remission of the disease and its local delivery is highly desired. In the present study, using the electrospinning method, we have developed a drug delivery system for Mesalamine with dual activity to enhance acid resistance as well as promote prebiotic activity. The psyllium Extracted-Mucilage was used due to prebiotic properties and stimulating beneficial bacteria in the gut and Poly(vinyl alcohol) was harnessed to improve electrospinning and a coating with Eudragit polymer to pH-responsivity. SEM images of prepared nanofibers demonstrated that uniform, highly smooth, and ultrafine nanofibers were formed without bead defects. Eudragit could significantly decrease Mesalamine release in the lower pH of a mimicked gastrointestinal microenvironment. Moreover, prepared nanofibers exhibited higher adhesion to the mucosal surface and prebiotic activity. This study demonstrated designing a multi-effect drug delivery system with prebiotic, mucous adhesion, and pH resistance activities in order to deliver the drug purposefully and increase the retention of Mesalamine in the intestine and colon.
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