Abstract
It is widely recognized diabetes represents a relevant public health issue worldwide, due to the remarkable social, economic and healthcare burden this disorder is responsible for, mainly through the development of chronic complications leading to increased morbidity and mortality in the affected individuals [1]. Diabetes-associated burden has been progressively becoming even more relevant, due to the overwhelming increase in the number of patients diagnosed with this disorder which has already attained the status of an epidemic condition, as demonstrated by the doubling of people living with diabetes observed over the last two years, reaching, overall, 415 million of individuals worldwide, in 2015 [2]. Notably, as reported by the International Diabetes Federation (IDF), such a trend is expected to continue over the next years, even to a greater extent, with estimates indicating a further increase in the number of subjects suffering from diabetes reaching 642 million by 2040 worldwide [2].
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