Abstract
The aim of the study was to investigate the relationship between the melting point and the supramolecular structure of three multi-component crystals of aliphatic dicarboxylic acids with 2,2′-bipyridine and to investigate the conformations of 2,2′-bipyridine in published multi-component crystals. The crystals were prepared using the solvent evaporation method and were characterized using single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC). The crystal structures were further analyzed using CrystalExplorer, and the results were correlated with the melting points. The results of the conformation analysis of the reported multi-component crystals of 2,2′-bipyridine are also presented.
Highlights
Co-crystallization is a crystal engineering technique that has been successfully employed in the preparation of new solid forms with improved physical and chemical properties [1,2]
Pharmaceutical co-crystals, in which an active pharmaceutical ingredient with one or more undesirable properties is co-crystallized with a benign compound, are recognized as one of the most successful applications of co-crystallization [3,4,5]
2,20 -bipyridine (BPY) is a versatile compound that is employed in the preparation of coordination compounds and multi-component crystals
Summary
Co-crystallization is a crystal engineering technique that has been successfully employed in the preparation of new solid forms with improved physical and chemical properties [1,2]. Structureproperty studies form a very important part of co-crystal and pharmaceutical co-crystal research [6,7,8,9]. The relationship between the supramolecular structure of a cocrystal and some of its physical properties is not yet fully understood. Understanding this relationship is very important and will assist in improving the design and synthesis of these compounds.
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