Abstract
The antiobesity molecular mechanisms of mulberry leave components were analyzed based on intestinal micro-ecology and metabolomics. An obesity model was established by feeding rats with a high-calorie diet. Rats were divided into seven groups: the obesity model control (MC), positive control (PC), mulberry leaf powder (MLP), mulberry leaf fiber (MLF), mulberry leaf polyphenols (MLPS), mulberry leaf fiber and polyphenols mixture (MLM), and normal control (NC), and fed daily for 6 consecutive weeks. The results demonstrated that the MLM group had the best efficiency on weight loss, indicating synergistic interactions between MLPS and MLF. The reduction of Firmicutes abundance, and the downstream Clostridiales, Lachnespiraceae, was a key pathway for the antiobesity effects. The increased abundances of Lactobacillus vaginalis and Lactobacillus gasseri might result in lipid metabolism disorder. The test groups regulated the amino acid and oligopeptides metabolic disorder tents to normal levels compared with the MC and NC groups.
Highlights
Obesity, caused by a combination of genetic and environmental factors, is associated with nutritional metabolic disorders [1]
The quantitative and qualitative determination of polyphenols in Mulberry leaf polyphenols group (MLPS) extract was presented in Nutrients 2019, 11, x FOR PEER REVIEW
The present study compared the treatment of Mulberry leaf powder (MLP), MLPS, Mulberry leaf fiber (MLF), and Mulberry leaf fiber/polyphenols mixture (MLM) on obesity and lipid metabolism related indexes in Diet Induced Obesity (DIO) rats together with the model control (MC), positive control (PC), and normal control (NC) groups
Summary
Obesity, caused by a combination of genetic and environmental factors, is associated with nutritional metabolic disorders [1]. When energy intake in the body is greater than energy consumption, the imbalance causes fat to accumulate. Obesity affects body appearance and induces a variety of chronic diseases [2]. The rapid growth of obesity worldwide since the 1970s has been a major public health challenge [3]. Obesity is closely related to the intestinal bacterial community. Conventionalizing adult germ-free mice with normal microbiota harvested from the cecum of conventionally raised mice increased body fat content by 60% in 10–14 days [4]
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