Abstract
Problem statement: To date, the therapeutic strategy efficacy against memory impairment induced by alcohol intoxication is still limited. The novel therapeutic strategy which is easy to approach, less toxic and less cost is required. Based on the role of oxidative stress in memory impairment induced by alcohol, the neuroprotective effect of substance possessing antioxidant has gained much attention. Therefore, we aimed to determine the effect of Morus alba fruits, substance possessing antioxidant, on spatial memory and brain damage in hippocampus. Approach: Male Wistar rats were induced alcoholism by increasing the alcohol concentration in drinking water gradually increased to 30% within 15-week period. Then, the alcoholic rats were orally given mulberry fruits powder at doses of 2, 10 and 50 mg kg-1 BW at a period of 14 days. The memory was assessed using Morris water maze after single administration and every 7 days until the end of the experimental period and at the end of experiment, hippocampus was isolated and determined the neuron density. In addition, the evaluation of Acetylcholinesterase (AChE) activity and Malondialdehyde (MDA) level were also performed. Results: Our results showed that all doses of mulberry fruits enhanced spatial memory and neurons density in hippocampus. The suppression of both AChE activity and MDA level were also observed. These results suggested that the neuroprotection of mulberry fruits might occur partly via the decreased oxidative stress damage while the cognitive enhancing effect might occur partly via the increased hippocampal neuron density and the suppression of AChE activity. Conclusion: Mulberry fruits can protect against brain damage and memory impairment induced by alcoholism. Therefore, mulberry fruits may be served as natural resource for developing food supplement against alcoholism. However, further researches about possible active ingredient and pharmacokinetic are required before moving forward to clinical trial study.
Highlights
Alcohol is recognized as one of the mostChronic ethanol exposures have been shown to induce impairments in a variety of tasks requiring spatial cognition
Effect of mulberry fruits on cognitive deficit induced by chronic ethanol intake: We have found that Vitamin C which used as positive control in this study significantly attenuated the increase in escape latency induced by alcohol administration after single, 7 and 14 days after mulberry administration (p
The current study demonstrated that mulberry fruits powder could mitigate memory impairment in animal model of alcoholism
Summary
Alcohol is recognized as one of the most. Chronic ethanol exposures have been shown to induce impairments in a variety of tasks requiring spatial cognition The memory impairment induced by used as psychoactive drug, but chronic and excessive chronic alcohol consumption was reported to be alcohol consumption can produce various alcohol- associated with the decreased cholinergic system related problem including social, economic and public (Arendt et al, 1989; Nordberg et al, 1982). Health problem with profound impacts on brain it was that chronic alcoholism produced the functions and behaviors. Corresponding Author: Jintanaporn Wattanathorn, Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand Tel: +66-43-348394 Fax: +66-43-348394 484. The mechanism of powders were kept in dark air tight bottle at -20°C
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