Abstract
Mucosal-associated invariant T cells in inflammatory bowel diseases: bystanders, defenders, or offenders?
Highlights
The quest for new therapeutics and better follow-up of patients with inflammatory bowel diseases (IBD) requires the clearest possible picture of the immunological mechanisms underlying these complex pathologies
We showed in our study that blood Mucosal-Associated Invariant T (MAIT) cells from Crohn’s disease (CD) patients showed an altered phenotype, increased in vivo proliferation, and, interestingly, a shift in cytokine production with decreased IFNγ and increased IL-17 production [5]
We reported that blood MAIT cells from CD patients show a shift in cytokine secretion with lower IFNγ and higher IL-17
Summary
The quest for new therapeutics and better follow-up of patients with inflammatory bowel diseases (IBD) requires the clearest possible picture of the immunological mechanisms underlying these complex pathologies. This pathway is absent in vertebrates, but many bacterial and fungal species produce riboflavin and MAIT cells-specific ligands. MAIT cells release TNFα, IFNγ and become cytotoxic; they produce IL-17 in specific conditions.
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