Abstract
Biopsy studies were made of the continent cecal reservoir and its ileal nipple valve in 13 patients with up to 9 years of postoperative observation. The morphology of the cecal mucosa was well preserved, showing only minor atrophy with slightly reduced villous height. Nonprogressive increase of inflammatory cells was found interstitially and there was a slight increase of collagen fibers. Histochemical studies revealed a shift, probably originating soon after the urinary diversion, from sulfomucins to sialomucins in most patients. Presumably, this shift was a secondary, nonspecific phenomenon. No correlation was found between the type of mucin and the result of urine culture. Ileal valve biopsies revealed severe mucosal atrophy and a considerable increase in the amount of collagen fibers.
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