Abstract

The unusually rapid development of large-scale vaccines against coronavirus disease 2019 (COVID-19) was a historical moment for clinical healthcare. However, it took precedence over the fundamental immunological work needed for a fuller understanding of the critical components of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Consequently, almost all studies of the immune response in COVID-19 have focused exclusively on serum antibodies and systemic cell-mediated immunity including innate responses [1].

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