Abstract
BackgroundPatients with celiac disease (CD), characterized histologically by villous atrophy (VA) of the small intestine, have an increased risk of ischemic heart disease (IHD) and atrial fibrillation (AF), risks that persist for years after commencing the gluten-free diet. It is unknown whether persistent VA on follow-up biopsy, rather than mucosal healing, affects the risk of IHD or AF.MethodsWe identified patients with histologic evidence of CD diagnosed at all 28 pathology departments in Sweden. Among patients who underwent a follow-up small intestinal biopsy, we compared patients with persistent VA to those who showed histologic improvement, with regard to the development of IHD (angina pectoris or myocardial infarction) or AF.ResultsAmong patients with CD and a follow-up biopsy (n = 7,440), the median age at follow-up biopsy was 25 years, with 1,063 (14%) patients who were ≥60 years at the time of follow-up biopsy. Some 196 patients developed IHD and 205 patients developed AF. After adjusting for age, gender, duration of CD, calendar period, and educational attainment, there was no significant effect of persistent VA on IHD (adjusted HR 0.97; 95%CI 0.73–1.30). Adjusting for diabetes had a negligible effect (adjusted HR 0.98; 95%CI 0.73–1.31). There was no significant association between persistent VA and the risk of AF (adjusted HR 0.98; 95%CI 0.74–1.30).ConclusionsIn this population-based study of patients with CD, persistent VA on follow-up biopsy was not associated with an increased risk of IHD or AF. Failed mucosal healing does not influence the risk of these cardiac events.
Highlights
Celiac disease (CD) is an immune-based disorder characterized by small intestinal inflammation and villous atrophy (VA) that is triggered by the ingestion of gluten in geneticallysusceptible individuals.[1]
After adjusting for age, gender, duration of celiac disease (CD), calendar period, and educational attainment, there was no significant effect of persistent VA on ischemic heart disease (IHD)
Significant association between persistent VA and the risk of atrial fibrillation (AF). In this population-based study of patients with CD, persistent VA on follow-up biopsy was not associated with an increased risk of IHD or AF
Summary
Celiac disease (CD) is an immune-based disorder characterized by small intestinal inflammation and villous atrophy (VA) that is triggered by the ingestion of gluten in geneticallysusceptible individuals.[1]. Patients with celiac disease (CD), characterized histologically by villous atrophy (VA) of the small intestine, have an increased risk of ischemic heart disease (IHD) and atrial fibrillation (AF), risks that persist for years after commencing the gluten-free diet. It is unknown whether persistent VA on follow-up biopsy, rather than mucosal healing, affects the risk of IHD or AF
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