Mucosal dosage form of lidocaine for toothache using hydroxypropyl cellulose and carbopol.

Abstract

In the present study, as a continuation of the previous work on a new mucosal dosage form for insulin using hydroxypropyl cellulose-H (HPC) and Carbopol-934 (CP), we attempted to develop a dosage form containing a local anesthetic for toothache, using lidocaine as a model drug in HPC and CP as the peripheral base. The dissolution profile of lidocaine was investigated with various mixing ratios of freeze-dried HPC/CP (FD-HPC/CP) to lidocaine in the core base, and the absorption when this dosage form was applied to the human gingiva was also studied. It was found that the rate in the dissolution test was delayed with increase in the amount of FD-HPC/CP in the core base and that the absorption of lidocaine was about 30% after 1 hour and then increased by about 10% of the initial amount per hour for 4 hours in preparations containing 5 and 10 mg of FD-HPC/CP.