Mucosal-Associated Invariant T Cells Are Altered in Patients with Hidradenitis Suppurativa and Contribute to the Inflammatory Milieu

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects up to 4% of the population, resulting in the development of nodules and abscesses in apocrine-bearing skin of the axillae, groin, buttocks, and the inframammary fold (Cosmatos et al., 2013). The pathogenesis of HS is still not fully understood, but emerging evidence has highlighted significant immune dysregulation and inflammation as key drivers of the disease (Kelly et al., 2014). Inflammatory cytokines such as IL-1b and IL-17 have all been identified as possible contributors to HS (Kelly et al., 2015; Matusiak et al., 2017; Witte-Händel et al., 2019).