MUCOCUTANEOUS REACTIONS TO DRUGS: 3 CASE REPORTS

Abstract

Stevens-Johnson syndrome (SSJ) and a toxic epidermal necrolysis (NET) are mucocutaneous reactions to drugs. Three cases of pharmacodermia are presented here. CASE 1: AGSS, 13, with SSJ with face, chest, perineum, and oral cavity lesions. Pharmacologic measures, debridement of devitalized areas, and laser therapy were adopted. She was discharged from the hospital after 14 days. CASE 2: MMS, 64, with deep vein thrombosis and Acute Renal Failure (ARF). She presented with pharmacodermia and was in the hospital to treat mucositis and skin lesions. Ten days later the rashes flared and mucositis was aggravated. Pharmacologic measures, protocols for mucositis, and control of mucocutaneous lesions were adopted. She died after 8 days. CASE 3: GSS, 14, with skin, oral, and mucosa lesions was treated in the ICU. Immunoglobulin and corticosteroids were used for SJS. He was discharged after 14 days. SSJ and NET are severe events mediated by the immune system and triggered by drugs. Decision-making should be fast and based on first symptoms. Stevens-Johnson syndrome (SSJ) and a toxic epidermal necrolysis (NET) are mucocutaneous reactions to drugs. Three cases of pharmacodermia are presented here. CASE 1: AGSS, 13, with SSJ with face, chest, perineum, and oral cavity lesions. Pharmacologic measures, debridement of devitalized areas, and laser therapy were adopted. She was discharged from the hospital after 14 days. CASE 2: MMS, 64, with deep vein thrombosis and Acute Renal Failure (ARF). She presented with pharmacodermia and was in the hospital to treat mucositis and skin lesions. Ten days later the rashes flared and mucositis was aggravated. Pharmacologic measures, protocols for mucositis, and control of mucocutaneous lesions were adopted. She died after 8 days. CASE 3: GSS, 14, with skin, oral, and mucosa lesions was treated in the ICU. Immunoglobulin and corticosteroids were used for SJS. He was discharged after 14 days. SSJ and NET are severe events mediated by the immune system and triggered by drugs. Decision-making should be fast and based on first symptoms.