Mucoadhesive nanofibrous membrane with anti-inflammatory activity

Abstract

For the higher patient compliance in periodontal disease, the drug delivery system should be released with a mucoadhesive membrane in a higher rate to minimize the sink condition in mouth. The herbal compounds have been well known as a branch of therapeutic agents, especially for inflammatory injuries. Herein, carbopol or carbomer was employed to prepare a matrix system containing a therapeutic agent, namely Ziziphus jujuba extract. The corresponding polymer was electrospun with polyacrylonitrile, and the release process was studied in the following. Approximately, 80% of the extract was released after 60 min following the Higuchi model and the anti-inflammation reaction of the extract was confirmed after stimulating inflammation of human umbilical vein endothelial cells by lipopolysaccharide. Also, the mechanical mucoadhesion of prepared scaffold was exposed that approximately 4 N/m2 was required to separate from mucoadhesive substrates. Also, Fourier transform infrared spectroscopy confirmed the presence of cyclic saccharides belonged to Z. jujuba extract. All results have approved that the membrane prepared with carbopol and Z. jujuba extract could be used as a patch for the treatment of periodontal injuries.