MUCOADHESIVE MICROSPHERES OF QUINAPRIL HYDROCHLORIDE FOR THE MANAGEMENT OF HYPERTENSION VIA ORAL ROUTE: AN APPROACH

Abstract

The objective of the present study is to create a new approach to design and evaluate mucoadhesive microspheres for oral controlled release. The quinapril hydrochloride microspheres with a coat consisting of alginate polymer i.e. sodium alginate in combination of mucoadhesive mineral origin chitin molecule polymer chitosan and galactomannan polymer i.e. guargum were prepared by an ionic gelation process. The microspheres were evaluated for morphological character, particle size, micromeritic properties, percentage entrapment efficiency, Swelling Index, in-vitro wash-off test, in-vitro release studies and in vivo mucoadhesion behavior in albino rabbits. The result of mucoadhesive microspheres were identified spherical and have free flowing properties. The percent of drug loading efficiency was 89.9 to 95.6%. The microspheres showed good mucoadhesive property during the in vitro wash-off test. The drug quinapril hydrochloride released from polymer matrix mucoadhesive system from these was slow and extended over 12 h duration on the composition of coat. Mucoadhesive microspheres provide the capability to adhere on the mucosal tissue of stomach. Quinapril Hydrochloriderelease mucoadhesive pulsatile multiunit dosage forms was found to be slow and extended period of time. The drug discharge ratio was dependent on the composition of polymer and stirring speed used during the formulation. The release of drug was prolonged through the matrix system produced after swelling of polymeric composition of coat within mucoadhesive polymers and sustained drug release up to 12 h duration. The result concluded that prepared mucoadhesive microspheres best suited for oral controlled release of quinapril hydrochloride for the management of hypertension via oral route.