Mucoadhesive Drug Delivery Systems: A Review of Recent Developments

Sharaf Alawdi,Ajay B Solanki

doi:10.47631/jsrmbs.v2i1.213

Abstract

Purpose: The aim of this article is to present a review of mucoadhesion drug delivery systems. The review covers the mucoadhesive concepts, polymers used, theories and mechanisms of mucoadhesion, and factors affecting the mucoadhesive dosage forms. Study Design: An extensive review was carried out on mucoadhesion formulations, applications, mechanisms, theories, and polymers used in these dosage forms. Results: Mucoadhesive drug delivery system can interact with the mucus membrane, which covers the mucin molecules and mucosal epithelial surface. This interaction leads to an increment of the dosage form residence time at the site of absorption and hence increasing the bioavailability, efficacy of drugs, and improving therapeutic outcomes. Polymers are used to provide muco-adhesion of the dosage form, enhancing drug release pattern, solubility and dissolution of inadequately soluble drugs. Conclusion: Mucoadhesive drug delivery systems were found to be the best alternative approaches for the traditional dosage forms to enhance bioavailability of poorly soluble drugs and to avoid GIT degradation and first pass metabolism of some drugs.

Highlights

Since the early 1980s, the term of mucoadhesion has earned considerable attention in pharmaceutical technology(Mamatha et al, 2012) when professor Joseph R
Robinson from Wisconsin University pioneered the term of mucoadhesion as a new approach to extend the residence time of drugs used on the ocular surface(Verma et al, 2011)
Relevant databases were searched through Google Scholar and PubMed, and the keywords entered were Mucoadhesive Drug Delivery Systems, mucoadhesion, mucoadhesive forms, and factors affecting mucoadhesion

Summary

Introduction

Since the early 1980s, the term of mucoadhesion has earned considerable attention in pharmaceutical technology(Mamatha et al, 2012) when professor Joseph R. Robinson from Wisconsin University pioneered the term of mucoadhesion as a new approach to extend the residence time of drugs used on the ocular surface(Verma et al, , 2011). Mucoadhesive drug delivery systems promote the dosage form's residence time at the absorption site. They facilitate a close interaction of the dosage form with the. Several mucoadhesive drug delivery systems have been developed for nasal, buccal, oral, vaginal, and rectal routes for both local and systemic effects(Edsman & Hägerström, 2005; Sofi, Abdal-Hay, Ivanovski, Zhang, & Sheikh, 2020). The aim is to highlight the factors that affect the mucoadhesive dosage forms. For this purpose, an extensive literature review was conducted. Relevant databases were searched through Google Scholar and PubMed, and the keywords entered were Mucoadhesive Drug Delivery Systems, mucoadhesion, mucoadhesive forms, and factors affecting mucoadhesion

Literature Review

Mechanism of Mucoadhesion

Conclusion