Abstract
Microsphere constitutes an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Due to their short residence time, bioadhesive characteristics can be coupled to microsphere to develop mucoadhesive microsphere. Bioadhesion defined as state in which two materials, at least one of which is biological in nature, are held together for a prolonged time by the way of interfacial forces. Microsphere are the carrier around drug delivery system in which particle size in ranges from 1-1000 μm range in diameter having a core of drug and entirely outer layers of polymers as coating material. Mucoadhesive microsphere have advantages like efficient absorption and enhanced bioavailability of drugs due to high surface of volume ratio, a much more intimate contact with mucus layer, controlled and sustained release of drug from dosage form and specific targeting of drug to absorption site. This study aim to provide an overview of various aspects of mucoadhesive microsphere based on various polymers, method of preparation of mucoadhesive microsphere, method of evaluation and their applications in drug delivery system.Keywords: Mucoadhesive, microsphere, bioavailability.
Highlights
Microsphere are small spherical particles, sometimes referred to as microparticles
Bioadhesion can be defined as the state in which two materials, at least one of which is biological in nature mucoadhesive microsphere have advantages like efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio, a much more intimate contact with the mucus layer and specific targeting of Corresponding author: Preeti Singh
Novel drug delivery systems achieved a great interest in recent years in the field of modern pharmaceutical formulations
Summary
Microsphere are small spherical particles (typically 1 μm to 1000 μm), sometimes referred to as microparticles. Bioadhesion can be defined as the state in which two materials, at least one of which is biological in nature mucoadhesive microsphere have advantages like efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio, a much more intimate contact with the mucus layer and specific targeting of Corresponding author: Preeti Singh. The major components of all mucus gels are mucin glycoprotein, water, lipids, and inorganic salts If these materials are incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug will be released at the site for an extended period of time. Microsphere, in general, have the potential to be used for targeted and controlled release drug delivery; coupling of mucoadhesive properties to microsphere has additional advantages like, a much more intimate contact with the mucus layer, efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio.
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