Muco-cutaneous gamma G polyclonal plasmacytoma with two bence jones proteins (BJK and BJL)

Abstract

A 21 year old woman who has had joint pains and extraosseous plasmacytomas since the age of 9 is presented. The tumors are localized in the larynx, the nasal mucosa and the skin of the cheeks. Bone marrow examinations and bone X-rays have failed to show manifestations of the disease. Electrophoretic studies have shown a hyperproteinemia with hypergammaglobulinemia of the diffuse type. Immunochemical analysis demonstrated that a large amount of a globulin with H specificity for the gamma G type was present in the serum. Abnormal concentrations of both Kappa and Lambda types of Bence Jones proteins were found in the urine. Tumor cells reacted only with antiserum for gamma G when tested on immunofluorescence. The slow progress of the disease and the lack of response to therapy are remarkable.