Mucinous tubular and spindle cell carcinoma very rare variant kidney cancer: Case report

Abstract

Introduction and importanceMucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the kidney is a rare variant, first classified by WHO in 2004 classification of RCC. MSCC has distinct morphology and immunohistochemistry unlike challenging previous renal tumor classifications. Despite its rarity, MTSCC diagnosis is important due to its unique characteristics. Case presentationWe present a 56-year-old female with a decade-long history of right-side abdominal pain and swelling. Physical examination revealed a 15*10 cm mass on the right flank. Imaging indicated a heterogeneously enhancing right renal mass, diagnosed as localized right Renal Cell Carcinoma (RCC). A radical nephrectomy was performed, and the biopsy confirmed MTSCC. The patient was discharged on the 6th post-op day, with no adjuvant treatment due to localized tumors. Clinical discussionMTSCC, constituting <1 % of RCC, primarily affects females (1:3–4) with an indolent course. Radical nephrectomy is the preferred treatment, offering a favorable prognosis. However, a small percentage may experience metastasis, necessitating mandatory follow-up. ConclusionMTSCC of the kidney is a rare RCC variant with an excellent prognosis. Surgical excision, specifically radical nephrectomy, is the mainstay of treatment. Adjuvant therapy may not be required for localized tumors. Postoperative follow-up is crucial, despite the rare risk of metastasis reported in some cases.