Mucinous Adenocarcinoma of Prostate: A Case Report and Review of Literature

Guang Zhen Wu,Tang Qz,Zhang Zhi W,Quan Lin Li,Wang Qi Fei

doi:10.4172/2165-7920.1000955

Abstract

Mucinous adenocarcinoma(MC) of prostate is extremely rare, with an incidence of approximately 0.2% Mucinous adenocarcinoma of the prostate usually has no obvious symptoms, its usual clinical symptom are frequency, dysuria, difficulty in voding which are similar to benign prostate hypertension, the diagnosis of mucinous adenocarcinoma is made only when extraluminal pools of mucin involve at least 25% of the tumor volume at prostatectomy, the different with the prostate acinar cell carcinoma is that MC is more likely to occur in skeletal and visceral metastases. Some studies suggest that 77.8% of MC patients’ PSA will be increased, and there is no significant difference in the degree of increase compare with the prostate acinar cell carcinoma. This case report describes the excellent clinical course of a 74-year-old patient with mucinous adenocarcinoma of the prostate, treated by trans-urethral resection of prostate (TURP). In our case, mucinous adenocarcinoma of the prostate does not appear to behave differently than acinar prostate cancer, and with a review of the current literature.

Highlights

Mucinous adenocarcinoma(MC) of prostate is extremely rare, with an incidence of approximately 0.2% Mucinous adenocarcinoma of the prostate usually has no obvious symptoms, its usual clinical symptom are frequency, dysuria, difficulty in voding which are similar to benign prostate hypertension, the diagnosis of mucinous adenocarcinoma is made only when extraluminal pools of mucin involve at least 25% of the tumor volume at prostatectomy, the different with the prostate acinar cell carcinoma is that MC is more likely to occur in skeletal and visceral metastases
Cystoscopy revealed the papillary tumor was found in the neck of the bladder and the posterior urethral (Figure 3): The patient underwent a preoperative biopsy of the tumor, which revealed the result of adenocarcinoma with immunohistochemical: CK(20)(-), 34Be12(), CK(7), CK8/18 (+), P504S(+), PSA(weak+), PSAP(weak+), p63 (-) (Figure 4), CT scan and ECT scan were negative for metastases
Mucinous adenocarcinoma of the prostate was first described by McNeal in 1991 and were observed in 13 out of 33 mucin-producing prostatic adenocarcinomas

Summary

Introduction

Mucinous adenocarcinoma(MC) of prostate is extremely rare, with an incidence of approximately 0.2% Mucinous adenocarcinoma of the prostate usually has no obvious symptoms, its usual clinical symptom are frequency, dysuria, difficulty in voding which are similar to benign prostate hypertension, the diagnosis of mucinous adenocarcinoma is made only when extraluminal pools of mucin involve at least 25% of the tumor volume at prostatectomy, the different with the prostate acinar cell carcinoma is that MC is more likely to occur in skeletal and visceral metastases. Cystoscopy revealed the papillary tumor was found in the neck of the bladder and the posterior urethral (Figure 3): The patient underwent a preoperative biopsy of the tumor, which revealed the result of adenocarcinoma with immunohistochemical: CK(20)(-), 34Be12(), CK(7), (weak+), CK8/18 (+), P504S(+), PSA(weak+), PSAP(weak+), p63 (-) (Figure 4), CT scan and ECT scan were negative for metastases.

Results

Conclusion