Abstract
Both pancreas head ductal carcinoma (PHDC) and distal bile duct carcinoma (DBDC) are located within the pancreas head/intra-pancreatic bile duct region, and are the most aggressive malignancies with poor patient prognosis. In the present study, we demonstrated clinicopathological features and patients prognosis of PHDC/ DBDC. We examined total 87 surgically resected cases of PHDC (40 cases) and DBDC (47 cases). PHDC showed frequent neural invasion (85.0%) and lymph node metastasis (77.5%), compared with DBDC (57.4% and 40.4% respectively), resulting in the poorer prognosis (P=0.0219) than DBDC. In addition, PHDC expressed MUC2 (10.0%) and MUC6 (25.0%) less frequently, compared with DBDC (36.2% and 55.3%, respectively). MUC5AC-negative PHDC exhibited significantly poorer patient’s prognosis, compared with MUC5AC-positive PHDC (P=0.0111), MUC5ACpositive DBDC (P=0.000162), and MUC5AC-negative DBDC (P=0.00416). In conclusion, MUC5AC-negative PHDC showed significantly poor patient’s prognosis. Hirosaki Med.J. 66:28―37,2015
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