Abstract
MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005
Highlights
An increase in the quantities of the metabolites of the cyclooxygenase and 5-lipoxygenase enzymatic pathways has been demonstrated in sputum derived from asthmatic patients[1,2] and patients with chronic bronchitis.[3,4] In clinical studies,[5] involving patients treated with inhibitors of these enzymatic pathways, a significant reduction in sputum volume has been reported
Initial reports have indicated that exposure of human airway cultured cell explants to indomethacin caused an increase in mucus secretion, when the incorporation of 3H-glucosamine was used as the index of glycoprotein secretory activity.[8]
Steroid inhalation or injection has been reported to significantly reduce sputum production in asthmatic patients[2] and in isolated human airways, steroids significantly reduced glycoprotein secretion.[9]. These data suggest that further studies concerning the effects of inhibition of the cyclooxygenase and/or lipoxygenase pathways on secretory activity may be warranted since there remains considerable controversy concerning such inhibition in the human respiratory tract
Summary
An increase in the quantities of the metabolites of the cyclooxygenase and 5-lipoxygenase enzymatic pathways has been demonstrated in sputum derived from asthmatic patients[1,2] and patients with chronic bronchitis.[3,4] In clinical studies,[5] involving patients treated with inhibitors of these enzymatic pathways, a significant reduction in sputum volume has been reported. These observations suggest that eicosanoids may be involved in airway inflammation and modify the secretory activity in the human respiratory tract. Conclusion: These results suggest that the cyclooxygenase and 5-lipoxygenase metabolic pathways play little or no role in the release of MUC5AC from human airways
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