Abstract
Streptococcus iniae (S. iniae) is a major pathogen that is capable of resulting severe economic loss to cultured fish. Steadily iron availability from micro-environment is an important virulence factor for pathogens, and S. iniae encodes the iron-transporter MtsABC to accomplish heme utilization, but very little was known about the mechanisms involved in regulating and maintaining iron balance in S. iniae. In this study, the role of a putative iron-dependent transcriptional regulator MtsR was investigated, and the results showed that MtsR regulated the expression of iron-transport mtsABC to control iron homeostasis in S. iniae.
Highlights
Iron plays a significant role in many biological processes [1] [2] [3], and is an essential nutrient that Streptococcus iniae (S. iniae) needs to survive
Our previous study indicated that the iron-transporter mtsABC of S. iniae HD-1 was involved in hemeutilization [4] [5], but very little was known about the mechanisms involved in regulating and maintaining iron balance in S. iniae
The results showed that the growth of S. iniae HD-1 was inhibited by adding nitrilotriacetic acid trisodium salt (NTA) to brain heart infusion (BHI) medium supplemented with additional cations, and this inhibition was the result of iron limitation
Summary
Iron plays a significant role in many biological processes [1] [2] [3], and is an essential nutrient that Streptococcus iniae (S. iniae) needs to survive. Our previous study indicated that the iron-transporter mtsABC of S. iniae HD-1 was involved in hemeutilization [4] [5], but very little was known about the mechanisms involved in regulating and maintaining iron balance in S. iniae. These two families regulated the production of iron-transport systems, and in pathogens, they often controlled the expression of virulence factors as well
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