Abstract
mTORC1 sustains vision in retinitis pigmentosa.
Highlights
Follow this and additional works at: https://escholarship.umassmed.edu/oapubs Part of the Eye Diseases Commons, Molecular and Cellular Neuroscience Commons, and the Ophthalmology Commons
We recently proposed a new model where cone loss is caused by a nutrient shortage induced by the collapse of the retinal architecture as rods die [2]
Our hypothesis for cone loss was based on the findings that cones increase the expression of metabolic genes at the onset of cone death, and display signs of prolonged starvation during degeneration
Summary
Follow this and additional works at: https://escholarship.umassmed.edu/oapubs Part of the Eye Diseases Commons, Molecular and Cellular Neuroscience Commons, and the Ophthalmology Commons. Follow this and additional works at: https://escholarship.umassmed.edu/oapubs Part of the Eye Diseases Commons, Molecular and Cellular Neuroscience Commons, and the Repository Citation Petit L, Punzo C. The genetic defects are specific to the night active rod photoreceptors; cones, which mediate daytime and high acuity vision, die as well [1].
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